(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid
GANODERIC ACID A
CAS: 81907-62-2
Molecular Formula: C30H44O7
(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid - Names and Identifiers
(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid - Physico-chemical Properties
| Molecular Formula | C30H44O7 |
| Molar Mass | 516.67 |
| Density | 1.22 |
| Melting Point | 118～123℃ |
| Boling Point | 690.1±55.0 °C(Predicted) |
| Specific Rotation(α) | + 146 °( c 0.1002,CHCl3) |
| Solubility | Soluble in chloroform, ethyl acetate and other organic solvents. |
| Appearance | White crystal |
| Color | White to Pale Yellow |
| pKa | 4.78±0.23(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| MDL | MFCD26131275 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Ganoderma lucidum, Ganoderma lucidum. |
| In vitro study | A lower doses of Ganoderic acid A enhance HLA class II-mediated antigen presentation and CD4+ T cell recognition of lymphoma. Ganoderic acid A promots cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression. Ganoderic acid Ainhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner. Ganoderic acid A effectively inhibites the proliferation of human osteosarcoma HOS and MG-63 cells in a dose-dependent manner, and induced obvious cell apoptosis in both cells. |
| In vivo study | Ganoderic acid A treatment significantly prolonged survival of EL4 challenged mice and decreased tumor metastasis to the liver. |
(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29189900 |
(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid - Reference
| Reference Show more | 1. Study on the quality control of Zhao Yanmiao Zhiyan niushujing et al. Renshenrongzhi capsule [J]. Journal of Food Safety and quality testing 2015(4):1369-1375. 2. Wen Baoqing, Li Wenqing, Lin kunxia, etc. Analysis of chemical constituents of Ganoderma lucidum by HPLC-QTOF MS [J]. Pharmacy Today, 2019, 029(011):761-764. 3. Muhua, Cai Ming, Xu Jing, et al. Comparison of chemical constituents and antioxidant activities between wall-broken and wall-removed spores of Ganoderma lucidum [J]. Science and Technology of food industry, 2020, 041(010):32-37,51 4. Fan Lei, Chen Zhang Jin, Wu chaqing, Wang faying. Quality Evaluation of Ganoderma lucidum based on multi-index component determination by UPLC-MS/MS [J]. China pharmacist, 2019,22(05):844-848. 5. Fan Lei, Chen Qinming, Chen Zhang Jin, et al. Study on quality control method of multiple evaluation of Ganoderma lucidum [J]. China pharmacist, 2018, v.21(05):76-80. 6. [IF = 2.45] Li Shengyun et al."Establishment and Application of a Method for the Determination of Ganoderic Acid A."J Food Quality. 2020;2020:6621853 7. [IF=5.279] Yan Zhang et al.Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer's Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis.J Agr Food Chem. 2021;69(47):14204-14214 |
(25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid - Reference Information
| Plant Source: | Ganoderma lucidum |
| biological activity | Ganoderic acid A can inhibit JAK-STAT3 signaling pathway, cell proliferation, survival rate and ROS. |
| Use | Ganoderma acid A has the effects of lowering blood lipid, lowering blood pressure, protecting liver and regulating liver function. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: inhibit the release of histamine cells, enhance the function of various organs of the digestive system, with lowering blood fat, lowering blood pressure, protecting liver, regulating liver function and so on. |
Last Update：2024-04-09 21:32:09
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